Detection of human papillomavirus (HPV) DNA type 6/11 in a conjunctival papilloma by in situ hybridization with biotinylated probes

Pathologica. Jul-Aug 1992;84(1092):483-8.

Abstract

Four cases of conjunctival papilloma in two different patients were examined by in situ hybridization for HPV DNA type 6/11, 16/18 and 31/33/51. Formalin-fixed and paraffin-embedded tissues were hybridized by biotinylated probes. One tumor and one of its recurrences showed nuclear positivity for HPV 6/11 in the superficial cells of the epithelium. The results suggest that HPV type 6/11 may be etiologic agent of conjunctival papillomas. The benign behavior of these neoplasms may be related to the etiologic role of this type of HPV.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Biotin*
  • Conjunctival Neoplasms / chemistry
  • Conjunctival Neoplasms / microbiology*
  • DNA Probes, HPV*
  • DNA, Neoplasm / analysis*
  • DNA, Viral / analysis*
  • Humans
  • In Situ Hybridization*
  • Male
  • Neoplasm Recurrence, Local
  • Papilloma / chemistry
  • Papilloma / microbiology*
  • Papillomaviridae / classification
  • Papillomaviridae / isolation & purification*
  • Papillomaviridae / pathogenicity

Substances

  • DNA Probes, HPV
  • DNA, Neoplasm
  • DNA, Viral
  • Biotin