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Review
, 70 Suppl, S73-7

The Calyx-Type Synapse of the Chick Ciliary Ganglion as a Model of Fast Cholinergic Transmission

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Review

The Calyx-Type Synapse of the Chick Ciliary Ganglion as a Model of Fast Cholinergic Transmission

E F Stanley. Can J Physiol Pharmacol.

Abstract

The calyx-type synapse of the embryonic chick ciliary ganglion is reviewed as a model of transmitter release from a vertebrate presynaptic nerve terminal. This nerve terminal is extensive in area, enabling the penetration with microelectrodes and the application of patch-clamp techniques. In other respects the calyx synapse is a typical fast-transmitting cholinergic nerve terminal. This synapse has been used to obtain the first recordings of action potentials and calcium currents in a vertebrate presynaptic nerve terminal and is the only preparation in which it has proved possible to record single calcium channels directly from the transmitter release sites. The calyx remains a powerful experimental preparation for the further analysis of the mechanism and control of neurotransmitter release in fast-transmitting nerve terminals.

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