A hospital based case-control study was conducted to define the role of some of the factors predisposing to hepatocellular carcinoma (HCC). It included 62 HCC cases and 62 age, sex and occupation matching control. Selected past history like schistosomal infection, jaundice, blood transfusion, contraceptive pills use, alcohol consumption and family history of cancer were examined. The history of schistosomiasis and that of jaundice show statistical significant differences.