Abstract
Sodium channels are the receptors for more than 10 distinct classes of biological toxins which act at five or more receptor sites. Brevetoxins and ciguatoxins act at neurotoxin receptor site 5. This receptor site is located on the alpha subunit of the sodium channel, and peptide segments in domain IV of that subunit are important in brevetoxin binding.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Ciguatoxins / metabolism
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Ciguatoxins / pharmacology
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Marine Toxins / metabolism
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Marine Toxins / pharmacology
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Neurotoxins / metabolism
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Neurotoxins / pharmacology
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Oxocins*
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Receptors, Drug / chemistry*
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Receptors, Drug / physiology
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Scorpion Venoms / metabolism
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Sodium Channels / chemistry*
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Sodium Channels / physiology
Substances
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Marine Toxins
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Neurotoxins
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Oxocins
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Receptors, Drug
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Scorpion Venoms
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Sodium Channels
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Ciguatoxins
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brevetoxin