Molecular properties of the sodium channel: a receptor for multiple neurotoxins

Bull Soc Pathol Exot. 1992;85(5 Pt 2):481-5.

Abstract

Sodium channels are the receptors for more than 10 distinct classes of biological toxins which act at five or more receptor sites. Brevetoxins and ciguatoxins act at neurotoxin receptor site 5. This receptor site is located on the alpha subunit of the sodium channel, and peptide segments in domain IV of that subunit are important in brevetoxin binding.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Ciguatoxins / metabolism
  • Ciguatoxins / pharmacology
  • Marine Toxins / metabolism
  • Marine Toxins / pharmacology
  • Neurotoxins / metabolism
  • Neurotoxins / pharmacology
  • Oxocins*
  • Receptors, Drug / chemistry*
  • Receptors, Drug / physiology
  • Scorpion Venoms / metabolism
  • Sodium Channels / chemistry*
  • Sodium Channels / physiology

Substances

  • Marine Toxins
  • Neurotoxins
  • Oxocins
  • Receptors, Drug
  • Scorpion Venoms
  • Sodium Channels
  • Ciguatoxins
  • brevetoxin