Dengue 2 virus enhancement in asthmatic and non asthmatic individual

Mem Inst Oswaldo Cruz. Oct-Dec 1992;87(4):559-64. doi: 10.1590/s0074-02761992000400016.


During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorrhagic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X2 p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / immunology
  • Asthma / blood
  • Asthma / complications*
  • Asthma / epidemiology
  • Asthma / immunology
  • Cells, Cultured
  • Cuba / epidemiology
  • Dengue / complications
  • Dengue / immunology
  • Dengue / microbiology*
  • Dengue Virus / immunology
  • Dengue Virus / physiology*
  • Female
  • Humans
  • Leukocytes / microbiology
  • Macrophages / physiology
  • Male
  • Middle Aged
  • Prevalence
  • Virus Cultivation
  • Virus Replication*


  • Antibodies, Viral