Forty years have gone by since the first case of total hypertrophy of the lower limb, associated with plane vascular naevus and partial "banded" osteosclerosis, was published, in 1935 by Al Rădulescu. No similar case was found in this time. The authors present now two cases of Rădulescu syndrome, identical with the first case, demonstrated with clinical, radiological and morphopathologic elements. A detailed differential diagnosis is made, which confirms the Rădulescu syndrome, a separate, well-defined morbid entity.