Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer

Lancet. 1992 Jan 18;339(8786):139-43. doi: 10.1016/0140-6736(92)90208-k.


Genetic alterations are believed to be important in the origin and dissemination of breast cancer. Cytogenetic rearrangements on chromosome 7 are common in breast tumours. We used the c-met proto-oncogene probe, which detects sequences on chromosome 7q31, to analyse tumour and blood leucocyte DNA samples from 245 patients with primary breast cancers. The pmetH polymorphic probe detected a high frequency of allele loss (40.5%) among the 121 informative (heterozygous) patients. This genetic alteration was not significantly associated with standard prognostic features including tumour size, histopathological grade, and lymph-node or steroid receptor status. However, patients with loss of heterozygosity on chromosome 7q31 in primary tumour DNA had significantly shorter metastasis-free survival (p = 0.00022) and overall survival (p = 0.0036) after surgery than patients without this alteration. These findings indicate that this region of chromosome 7 might be the site of a breast tumour or metastasis suppressor gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Analysis of Variance
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / mortality
  • Breast Neoplasms / physiopathology
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 7*
  • DNA, Neoplasm / genetics*
  • Female
  • Follow-Up Studies
  • Heterozygote*
  • Humans
  • Mutation / genetics*
  • Polymorphism, Restriction Fragment Length
  • Prognosis
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-met
  • Retrospective Studies
  • Survival Analysis


  • DNA, Neoplasm
  • MAS1 protein, human
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-met