5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

Neuron. 1992 Jan;8(1):199-203. doi: 10.1016/0896-6273(92)90121-s.

Abstract

A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT3 antagonists might result from blockade of such synapses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology
  • 6-Cyano-7-nitroquinoxaline-2,3-dione
  • Action Potentials / drug effects
  • Amygdala / physiology*
  • Animals
  • Electric Stimulation
  • Imidazoles / pharmacology
  • Indoles / pharmacology
  • Membrane Potentials / drug effects
  • Ondansetron
  • Quinoxalines / pharmacology
  • Rats
  • Receptors, Serotonin / physiology*
  • Serotonin / pharmacology*
  • Serotonin Antagonists / pharmacology
  • Synapses / physiology
  • Tropisetron
  • gamma-Aminobutyric Acid / physiology

Substances

  • Imidazoles
  • Indoles
  • Quinoxalines
  • Receptors, Serotonin
  • Serotonin Antagonists
  • GR 67330
  • Serotonin
  • Ondansetron
  • gamma-Aminobutyric Acid
  • Tropisetron
  • 6-Cyano-7-nitroquinoxaline-2,3-dione
  • 2-Amino-5-phosphonovalerate