Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

Nature. 1992 Jan 2;355(6355):50-5. doi: 10.1038/355050a0.


Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 6-Cyano-7-nitroquinoxaline-2,3-dione
  • Animals
  • Electric Stimulation / methods
  • Evoked Potentials / drug effects
  • Hippocampus / physiology*
  • In Vitro Techniques
  • N-Methylaspartate / pharmacology*
  • Pyramidal Tracts / physiology*
  • Quinoxalines / pharmacology
  • Synapses / drug effects
  • Synapses / physiology*
  • Tetrodotoxin / pharmacology


  • Quinoxalines
  • Tetrodotoxin
  • N-Methylaspartate
  • 6-Cyano-7-nitroquinoxaline-2,3-dione