Long-term follow-up of childhood Henoch-Schönlein nephritis

Lancet. 1992 Feb 1;339(8788):280-2. doi: 10.1016/0140-6736(92)91341-5.

Abstract

A study of long-term outcome of 78 subjects who had had Henoch-Schönlein nephritis during childhood (at a mean of 23.4 years after onset) shows that severity of clinical presentation and initial findings on renal biopsy correlate well with outcome but have poor predictive value in individuals. 44% of patients who had nephritic, nephrotic, or nephritic/nephrotic syndromes at onset have hypertension or impaired renal function, whereas 82% of those who presented with haematuria (with or without proteinuria) are normal. 17 patients deteriorated clinically from an initial assessment in 1971; 7 of these had apparently completely recovered in 1976. 16 of 44 full-term pregnancies were complicated by proteinuria and/or hypertension, even in the absence of active renal disease. These findings indicate that childhood Henoch-Schönlein nephritis requires long-term follow-up, especially during pregnancy.

Publication types

  • Comparative Study

MeSH terms

  • Biopsy
  • Child
  • Creatinine / blood
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney / pathology
  • Male
  • Nephritis / blood
  • Nephritis / etiology*
  • Nephritis / pathology
  • Nephritis / urine
  • Purpura, Schoenlein-Henoch / blood
  • Purpura, Schoenlein-Henoch / complications*
  • Purpura, Schoenlein-Henoch / pathology
  • Purpura, Schoenlein-Henoch / urine
  • Remission, Spontaneous
  • Time Factors

Substances

  • Creatinine