brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2

Cell. 1992 Feb 7;68(3):561-72. doi: 10.1016/0092-8674(92)90191-e.

Abstract

The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila. Loss-of-function brm mutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient expression of the homeotic genes of the Antennapedia and Bithorax complexes. The brm gene encodes a 1638 residue protein that is similar to SNF2/SWI2, a protein involved in transcriptional activation in yeast, suggesting possible models for the role of brm in the transcriptional activation of homeotic genes. In addition, both brm and SNF2 contain a 77 amino acid motif that is found in other Drosophila, yeast, and human regulatory proteins and may be characteristic of a new family of regulatory proteins.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • Drosophila / genetics*
  • Gene Library
  • Genes
  • Genes, Homeobox*
  • Genes, Regulator*
  • Molecular Sequence Data
  • Morphogenesis / genetics
  • Nuclear Proteins*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins
  • Sequence Alignment
  • Trans-Activators / chemistry
  • Trans-Activators / genetics*
  • Transcription Factors / genetics
  • Transcription, Genetic / genetics

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors
  • Adenosine Triphosphatases
  • SNF2 protein, S cerevisiae

Associated data

  • GENBANK/M84159
  • GENBANK/M84160
  • GENBANK/M85049
  • GENBANK/S72766
  • GENBANK/S72767
  • GENBANK/S72768
  • GENBANK/S72769
  • GENBANK/S72771
  • GENBANK/S82271
  • GENBANK/X63098