Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

Lancet. 1992 Feb 22;339(8791):458-9. doi: 10.1016/0140-6736(92)91061-c.


Insulin-dependent diabetes is characterised by autoantibodies to several pancreatic-islet-cell antigens, including glutamate decarboxylase. We measured the proliferative responses to this antigen of peripheral-blood mononuclear cells from patients with newly diagnosed insulin-dependent diabetes, relatives of diabetic patients, and healthy controls. The likelihood of a positive response was substantially greater among the diabetic patients and relatives positive for islet-cell autoantibodies (ICA) than among subjects at low risk of diabetes (controls and ICA-negative relatives). Glutamate decarboxylase may have a pathogenetic role in insulin-dependent diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoantibodies / immunology
  • Culture Media
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / immunology*
  • Glutamate Decarboxylase / pharmacology*
  • Humans
  • Islets of Langerhans / immunology
  • Leukocytes, Mononuclear / drug effects*
  • Leukocytes, Mononuclear / immunology
  • Lymphocyte Activation*


  • Autoantibodies
  • Culture Media
  • Glutamate Decarboxylase