Differential Effects of CD4+ and CD8+ Cells in Acute, Systemic Murine Candidosis

J Leukoc Biol. 1992 Mar;51(3):305-6. doi: 10.1002/jlb.51.3.305.

Abstract

Monoclonal antibody (mAb) depletion was used to assess contributions of CD4+ and CD8+ cells in resistance to systemic murine Candida albicans infection. Depletion of CD8+ cells did not influence either survival or mean survival time (MST); however, depletion of CD4+ cells significantly enhanced both survival and MST. Combined depletion of both CD4+ and CD8+ cells significantly lengthened the MST but did not enhance survival. A protective influence of CD8+ cells could be deduced but, to be manifested, required depletion of an overshadowing immunopathologic CD4+ response.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8 Antigens / analysis*
  • Candidiasis / immunology*
  • Candidiasis / pathology*
  • Disease Models, Animal
  • Female
  • Immunity, Innate
  • Mice
  • Mice, Inbred BALB C
  • T-Lymphocytes / immunology*

Substances

  • CD8 Antigens