Stereospecific actions of 2,5-dimethoxy-4-methylamphetamine (DOM) on colonic temperature in the rat at various ambient temperatures

Br J Pharmacol. 1976 Aug;57(4):547-50. doi: 10.1111/j.1476-5381.1976.tb10383.x.


The R(-) and S(+)-isomers of 2,5-dimethoxy-4-methylamphetamine (DOM) produce a dose-dependent hypothermia in rats kept in the cold (6 degrees C). 2 This hypothermia was linearly dependent upon ambient temperature and the R(-)-isomer was considerably more potent than the S(+)-isomer. 3 A statistically significant tachyphylaxis was observed when R(-)-DOM was administered on two successive days. The response seven days after the second injection was similar to that on the first day of injection. 4 The hypothermia induced by R(-) and S(+)-DOM was antagonized by methysergide but not by p-chlorophenylalanine (PCPA) or pimozide. Methysergide, PCPA or pimozide alone did not elicit hypothermia at the doses used. The results indicate that R(-) and S(+)-DOM act at post-synaptic 5-hydroxytryptamine receptors.

Publication types

  • Comparative Study

MeSH terms

  • 2,5-Dimethoxy-4-Methylamphetamine / antagonists & inhibitors
  • 2,5-Dimethoxy-4-Methylamphetamine / pharmacology*
  • Amphetamines / pharmacology*
  • Animals
  • Body Temperature / drug effects*
  • Colon
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Fenclonine / pharmacology
  • Male
  • Methysergide / pharmacology
  • Pimozide / pharmacology
  • Rats
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tachyphylaxis
  • Temperature


  • Amphetamines
  • 2,5-Dimethoxy-4-Methylamphetamine
  • Pimozide
  • Fenclonine
  • Methysergide