Quantitative assessment of psychomotor activity in patients with neuroleptic-induced akathisia

Prog Neuropsychopharmacol Biol Psychiatry. 1992 Jan;16(1):27-37. doi: 10.1016/0278-5846(92)90005-y.


1. An ambulatory activity monitor with solid-state memory was employed to obtain 24-hour activity data in 29 neuroleptic-treated hospitalized patients and 9 normal controls. 2. The activity monitor is a piezoelectric device which was strapped to the non-dominant ankle. Activity was recorded in 5-minute epochs throughout the 24-hour period. 3. In contrast to patients with mania (N = 15) and schizophrenia (N = 4), depressed patients (N = 9) had higher clinical ratings of akathisia and lower levels of daytime activity. 4. Manic and depressed patients showed a delay of peak activity (= acrophase). 5. Quantifiable alterations in rest-activity rhythms may occur in neuroleptic-induced akathisia but measurement of activity may be complicated by the patient's psychiatric disorder.

MeSH terms

  • Adolescent
  • Adult
  • Antipsychotic Agents / adverse effects*
  • Bipolar Disorder / chemically induced
  • Bipolar Disorder / psychology
  • Circadian Rhythm / drug effects
  • Depression / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Activity / drug effects*
  • Psychomotor Agitation / psychology*
  • Schizophrenic Psychology


  • Antipsychotic Agents