Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

Immunogenetics. 1992;35(5):309-15. doi: 10.1007/BF00189893.


We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L4 and B-G12 subregions originating from different naturally occurring haplotypes. Some of the tumors induced by the LTR, v-src, LTR DNA are repeatedly transplantable in syngeneic chickens, maintain unaltered provirus, and express v-src mRNA. Differences in the response to challenge with Rous sarcoma virus (RSV) and LTR, v-src, LTR DNA on a given experimental model are compared and possible involvement of an interaction between B-F/L and B-G region genes is considered. Regression of the LTR, v-src, LTR DNA-induced tumors did not prevent the formation and growth of tumors induced subsequently by RSV.

MeSH terms

  • Animals
  • Avian Sarcoma Viruses
  • Blotting, Northern
  • Blotting, Southern
  • Cell Division / genetics
  • Chickens
  • Cloning, Molecular
  • DNA, Neoplasm / physiology*
  • Genes, src / physiology*
  • Genetic Complementation Test
  • Neoplasms / genetics*
  • Neoplasms / microbiology
  • Polymorphism, Restriction Fragment Length
  • Proviruses
  • Repetitive Sequences, Nucleic Acid / physiology*


  • DNA, Neoplasm