Differences in T cell receptor restriction fragment length polymorphisms in patients with rheumatoid arthritis

Arthritis Rheum. 1992 Apr;35(4):465-71. doi: 10.1002/art.1780350417.

Abstract

Objective: The purpose of this study was to determine whether a T cell receptor (TCR) polymorphism, either by itself or in combination with particular HLA polymorphism, leads to susceptibility to rheumatoid arthritis (RA).

Methods: Eight restriction fragment length polymorphisms (RFLPs) detected with TCR gene segments were investigated in 46 individuals with RA and were compared with data from normal control subjects.

Results: A statistically significant difference in the genotype frequencies of a Taq I RFLP detected with the TCR alpha constant region (C alpha) gene was noted. In addition, when the DR4+ subpopulations were examined, the allelic frequency of a 2-kb Bam HI fragment detected with a V beta 8 gene was increased in the samples from RA patients (P less than 0.0086).

Conclusion: The results of this study suggest that germline differences in the TCR repertoire may be associated with RA, and that there is a contributory effect of DR4+ haplotypes with certain TCR haplotypes in susceptibility to RA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology
  • HLA-DR4 Antigen / analysis
  • Humans
  • Polymorphism, Restriction Fragment Length*
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / genetics

Substances

  • HLA-DR4 Antigen
  • Receptors, Antigen, T-Cell
  • Receptors, Antigen, T-Cell, alpha-beta