Pulmonary infiltration and eosinophilia associated with sulfasalazine therapy for ulcerative colitis: a case report and review of literature

Intern Med. 1992 Jan;31(1):108-13. doi: 10.2169/internalmedicine.31.108.


We report a 52-yr-old man with ulcerative colitis who developed sulfasalazine-induced pulmonary infiltration with eosinophilia (PIE syndrome), which resolved completely after withdrawal of this drug. Desensitization to sulfasalazine was successful, and allowed the patient to receive this drug without recurrence of the pulmonary toxicity. This is the first case of the sulfasalazine-induced PIE syndrome in Japan; a review of the world literature found no previous cases of successful desensitization following sulfasalazine-induced PIE syndrome.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Colitis, Ulcerative / drug therapy*
  • Desensitization, Immunologic
  • Drug Hypersensitivity / therapy
  • Humans
  • Male
  • Middle Aged
  • Pulmonary Eosinophilia / chemically induced*
  • Sulfasalazine / adverse effects*
  • Syndrome


  • Sulfasalazine