Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21

Genomics. 1992 Apr;12(4):745-9. doi: 10.1016/0888-7543(92)90304-b.


We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10*
  • Cricetinae
  • DNA Repair / genetics*
  • DNA Repair / radiation effects
  • Female
  • Genetic Linkage
  • Humans
  • Hybrid Cells
  • Male
  • Mutation
  • Pedigree
  • Polymorphism, Restriction Fragment Length
  • Restriction Mapping
  • Ultraviolet Rays