Dose-response study with high-dose inhaled salmeterol in healthy subjects

Br J Clin Pharmacol. 1992 Mar;33(3):342-5. doi: 10.1111/j.1365-2125.1992.tb04049.x.


A double-blind, placebo-controlled, cross-over study in 10 healthy male subjects has been carried out to investigate the non-pulmonary effects of single inhaled doses of salmeterol 100 micrograms, 200 micrograms and 400 micrograms and salbutamol 400 micrograms from a metered-dose inhaler. At all doses tested, salmeterol produced statistically significant changes in pulse rate, tremor, blood glucose and plasma potassium concentrations, compared with placebo. All changes were dosed related. A number of dose-related adverse events including tremor, awareness of heart beat and headache were reported after salmeterol administration.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Inhalation
  • Adrenergic beta-Agonists / pharmacology*
  • Adult
  • Albuterol / administration & dosage
  • Albuterol / analogs & derivatives*
  • Albuterol / pharmacology
  • Blood Glucose / analysis
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Humans
  • Male
  • Placebos
  • Potassium / analysis
  • Reference Values
  • Salmeterol Xinafoate


  • Adrenergic beta-Agonists
  • Blood Glucose
  • Placebos
  • Salmeterol Xinafoate
  • Albuterol
  • Potassium