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. Mar-Apr 1992;12(2):495-9.

A Single 24h Contact Time With Adriamycin Provokes the Emergence of Resistant Cells Expressing the Gp 170 Protein

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  • PMID: 1349797

A Single 24h Contact Time With Adriamycin Provokes the Emergence of Resistant Cells Expressing the Gp 170 Protein

S Chevillard et al. Anticancer Res. .

Abstract

We investigate here, in A549 cells, the influence of a single short (1h) or long (24h) adriamycin (ADR) contact time on the long-term cytotoxicity of the drug and on the emergence of resistant cells. In contrast to a 1 h ADR contact, a 24 h treatment provokes the emergence of resistant cells overexpressing the Gp170 protein and this overexpression is maintained for at least three months without any drug selection pressure.

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