Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination

Pediatr Neurol. Mar-Apr 1992;8(2):137-9. doi: 10.1016/0887-8994(92)90036-x.


A 6-year-old girl (Patient 1) and a 5-year-old boy (Patient 2) with acute disseminated encephalomyelitis after Japanese B encephalitis vaccination are reported. Drowsiness, paresthesias, and gait disturbance were observed at 14 days (Patient 1) and 17 days (Patient 2) after the vaccination; however, transient impairment of visual acuity was only found in Patient 1. Laboratory examinations revealed slow theta waves on electroencephalography and elevated myelin basic protein in the cerebrospinal fluid in both patients. The most striking feature on magnetic resonance imaging was the combination of white matter lesions and abnormal intensity signals of the thalamus. The administration of oral prednisolone (2 mg/kg/day) markedly improved the clinical findings and abnormal magnetic resonance imaging findings. A similar magnetic resonance imaging finding of abnormal intensity of the thalamus with deep white matter lesions has been reported in patients with Japanese B encephalitis; therefore, thalamic lesions may be related to the naturally occurring encephalitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Encephalitis Virus, Japanese / immunology*
  • Encephalitis, Japanese / diagnosis*
  • Encephalomyelitis, Acute Disseminated / diagnosis*
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Neurologic Examination
  • Tomography, X-Ray Computed*
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / adverse effects*


  • Viral Vaccines