Telencephalon-restricted Expression of BF-1, a New Member of the HNF-3/fork Head Gene Family, in the Developing Rat Brain

Neuron. 1992 May;8(5):957-66. doi: 10.1016/0896-6273(92)90210-5.

Abstract

We have previously characterized a novel transcription factor family in mammals, the HNF-3 family, by the members' homology to one another and to the Drosophila homeotic gene fork head. The expression of fork head is restricted to the anterior and posterior termini of the early fly embryo. Brain factor 1 (BF-1) is a new member of this family isolated from rat brain with an expression pattern and DNA binding specificity distinct from the HNF-3 genes. Expression is highly restricted in the developing neural tube to its rostral end, which gives rise to the telencephalon. These results suggest that BF-1 plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Blotting, Northern
  • Brain / growth & development*
  • Brain / metabolism
  • DNA / chemistry
  • DNA / isolation & purification
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Drosophila / genetics
  • Forkhead Transcription Factors
  • Gene Expression*
  • Genes, Homeobox
  • Male
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / metabolism
  • Rats
  • Rats, Inbred Strains
  • Sequence Homology, Nucleic Acid
  • Telencephalon / growth & development*
  • Telencephalon / metabolism
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • Forkhead Transcription Factors
  • Foxd1 protein, mouse
  • Nerve Tissue Proteins
  • Transcription Factors
  • Foxo1 protein, rat
  • DNA

Associated data

  • GENBANK/M87634