Selective D2 receptor stimulation induces dyskinesia in parkinsonian monkeys

Ann Neurol. 1992 May;31(5):551-4. doi: 10.1002/ana.410310514.


Stimulation of D1 striatal receptors has been proposed as the main mechanism mediating levodopa-induced dyskinesia in Parkinson's disease. We used (+)-PHNO, a selective D2 agonist, as the only treatment in 6 cynomolgus monkeys made parkinsonian by repeated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. All animals developed choreic dyskinesia after a mean treatment period of 12.8 days (range, 1-29). Administration of the D1 antagonist SCH-23390 1 hour before administration of (+)-PHNO did not change the dyskinesia. These results indicate that drug-induced dyskinesia in a primate model of Parkinson's disease is not solely induced by D1 receptor activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzazepines / pharmacology
  • Dopamine Agents
  • Dose-Response Relationship, Drug
  • Female
  • Macaca fascicularis
  • Male
  • Movement Disorders / etiology*
  • Oxazines
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / complications*
  • Receptors, Dopamine / physiology*
  • Receptors, Dopamine D2


  • Benzazepines
  • Dopamine Agents
  • Oxazines
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • naxagolide