Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development

Differentiation. 1992 Mar;49(2):93-9. doi: 10.1111/j.1432-0436.1992.tb00773.x.


We have analysed the expression pattern of the mouse homeobox containing gene Dlx-1. This gene harbors a homeodomain related to that found in the Drosophila distal-less (dll) gene. In addition to its expression in the developing forebrain, Dlx-1 is transcribed in several structures containing cells of neural crest origin such as the facial mesenchyme and various elements of the peripheral nervous system. Dlx-1 transcripts are also detected in the differentiating retina and during limb morphogenesis, in the apical ectodermal ridge. The possible involvement of Dlx-1 during facial, ocular and limb development is discussed.

MeSH terms

  • Animals
  • Cell Differentiation
  • Ectoderm / cytology
  • Embryonic and Fetal Development
  • Extremities / embryology*
  • Eye / cytology
  • Eye / embryology*
  • Face / embryology*
  • Gene Expression / genetics*
  • Genes, Homeobox / genetics*
  • Mice
  • Nervous System / cytology
  • Nervous System / embryology