Effect of adenosine and inosine on carbon tetrachloride-induced liver damage in rats

Indian J Physiol Pharmacol. 1992 Jan;36(1):39-42.

Abstract

Liver damage induced in rats by carbon tetrachloride (CCL4) was obvious macroscopically as well as microscopically in stained sections. Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (gamma-GT) were also significantly raised. Adenosine and inosine effectively countered the damage when these were given before and during the period during which CCl4 produces the typical damage. The beneficial effect was seen in biochemical as well as pathological studies.

Publication types

  • Comparative Study

MeSH terms

  • Adenosine / therapeutic use*
  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Carbon Tetrachloride Poisoning / complications*
  • Chemical and Drug Induced Liver Injury
  • Hemorrhage / chemically induced
  • Inosine / therapeutic use*
  • Liver / drug effects
  • Liver / enzymology
  • Liver / pathology
  • Liver Diseases / enzymology
  • Liver Diseases / prevention & control*
  • Male
  • Rats
  • Rats, Inbred Strains
  • gamma-Glutamyltransferase / blood

Substances

  • Inosine
  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Adenosine