Increased levels of circulating intercellular adhesion molecule 1 in Kawasaki disease

Arthritis Rheum. 1992 Jun;35(6):672-7. doi: 10.1002/art.1780350611.

Abstract

Objective: We investigated whether levels of intercellular adhesion molecule 1 (ICAM-1) antigen shed into the circulation increase during acute Kawasaki disease (KD). We also compared ICAM-1 levels in acute KD with those in anaphylactoid purpura (AP) and in measles.

Methods: Serum ICAM-1 levels were measured by a double-determinant immunoassay using 2 monoclonal antibodies in the FAST (Falcon assay screening test) system. Serum levels of tumor necrosis factor alpha (TNF alpha) were measured by a specific and sensitive sandwich enzyme immunoassay.

Results: Patients with KD, but not those with AP or measles, had increased levels of shed ICAM-1 antigen in serum samples obtained during acute stages. Moreover, during the acute stage, KD patients with coronary artery lesions (CAL) had still higher levels of shed ICAM-1 than did those without CAL. We found a positive correlation between serum levels of shed ICAM-1 and levels of TNF alpha during acute KD.

Conclusion: Our findings suggest that the serum ICAM-1 level is an important immunologic parameter for determining the severity of vascular damage during acute KD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion Molecules / blood*
  • Child, Preschool
  • Coronary Disease / blood
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Infant
  • Infant, Newborn
  • Intercellular Adhesion Molecule-1
  • Male
  • Mucocutaneous Lymph Node Syndrome / blood*
  • Mucocutaneous Lymph Node Syndrome / drug therapy
  • Time Factors
  • Tumor Necrosis Factor-alpha / analysis

Substances

  • Cell Adhesion Molecules
  • Immunoglobulins, Intravenous
  • Tumor Necrosis Factor-alpha
  • Intercellular Adhesion Molecule-1