Signal transduction in mesangial cells

J Am Soc Nephrol. 1992 Apr;2(10 Suppl):S100-6. doi: 10.1681/ASN.V210s100.


Phenotype, growth, and functional characteristics of glomerular mesangial "myofibroblasts" are under the control of multiple hormones, vasoactive agents, autacoids, and cytokines. Several parallel signal transduction pathways couple receptor occupancy with functional changes, including phospholipases C, A2, and D breakdown of membrane phospholipids, and adenylate/guanylate cyclase activation. Changes of cytosolic ion concentrations, cyclic nucleotide accumulation, and eicosanoid biosynthesis are currently interpreted as intracellular signals for protein kinase activation. Phosphorylation of multiple substrates by serine/threonine kinases C, A, and G or by tyrosine kinases directly coupled to receptors, is a final step in cell activation. Cross-talk between signal transduction pathways, along with the release of eicosanoids and cytokines acting as intercellular mediators, provides the potential for interactive regulation of glomerular cell functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Glomerular Mesangium / metabolism*
  • Guanylate Cyclase / metabolism
  • Humans
  • Phospholipases / metabolism
  • Protein Kinases / metabolism
  • Receptors, Cell Surface / metabolism
  • Signal Transduction / physiology*


  • Receptors, Cell Surface
  • Protein Kinases
  • Phospholipases
  • Adenylyl Cyclases
  • Guanylate Cyclase