Frequencies of X-ray-induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome-specific DNA libraries

A T Natarajan; R C Vyas; F Darroudi; S Vermeulen

doi:10.1080/09553009214550821

Frequencies of X-ray-induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome-specific DNA libraries

Int J Radiat Biol. 1992 Feb;61(2):199-203. doi: 10.1080/09553009214550821.

Authors

A T Natarajan¹, R C Vyas, F Darroudi, S Vermeulen

Affiliation

¹ MGC, Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.

PMID: 1351907
DOI: 10.1080/09553009214550821

Abstract

In situ hybridization with chromosome-specific DNA libraries was used to analyse radiation-induced stable translocations in human peripheral blood lymphocytes. These data were compared with radiation-induced unstable-type aberrations (dicentrics) in the same samples. The results indicate that far more stable aberrations are induced by radiation in comparison to unstable aberrations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Gene Library*
Humans
In Vitro Techniques
Lymphocytes / radiation effects
Lymphocytes / ultrastructure
Nucleic Acid Hybridization*
Translocation, Genetic*
X-Rays