Gastrulation in the Mouse: The Role of the Homeobox Gene Goosecoid

Cell. 1992 Jun 26;69(7):1097-106. doi: 10.1016/0092-8674(92)90632-m.

Abstract

Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activins
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA-Binding Proteins / analysis*
  • Embryonic Induction / drug effects
  • Embryonic Induction / genetics*
  • Gastrula / drug effects
  • Gene Expression
  • Genes, Homeobox*
  • Goosecoid Protein
  • Homeodomain Proteins*
  • Inhibins / pharmacology
  • Mesoderm / drug effects
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • RNA, Messenger / analysis
  • Repressor Proteins*
  • Transcription Factors*
  • Xenopus / embryology

Substances

  • DNA-Binding Proteins
  • Goosecoid Protein
  • Gsc protein, mouse
  • Homeodomain Proteins
  • RNA, Messenger
  • Repressor Proteins
  • Transcription Factors
  • Activins
  • Inhibins

Associated data

  • GENBANK/M63872
  • GENBANK/M84163
  • GENBANK/M84182
  • GENBANK/M85271
  • GENBANK/S72766
  • GENBANK/S72767
  • GENBANK/S72768
  • GENBANK/S72769
  • GENBANK/S72771
  • GENBANK/X63098