The renal removal of injected [14C] histamine from the blood in dogs

Br J Pharmacol Chemother. 1958 Mar;13(1):44-51. doi: 10.1111/j.1476-5381.1958.tb00188.x.

Abstract

The amounts of [(14)C]histamine in arterial blood, in renal venous blood and in urine during a steady intravenous infusion of [(14)C]histamine were measured in five anaesthetized dogs. The extraction ratio for [(14)C]histamine was 0.7 to 0.8, indicating that the histamine was efficiently taken up from the blood by the kidney. Only a small part (14 to 18%) of the [(14)C]histamine removed from the blood by the kidney appeared in the urine as histamine. Evidence was obtained that [(14)C]histamine was metabolized in the kidney not only by histaminase (diamine oxidase) but also by the histamine methylating enzyme.

MeSH terms

  • Amine Oxidase (Copper-Containing)*
  • Animals
  • Body Fluids*
  • Dogs
  • Histamine / blood*
  • Infusions, Intravenous*
  • Injections*
  • Kidney / metabolism*
  • Renal Veins*

Substances

  • Histamine
  • Amine Oxidase (Copper-Containing)