Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex

EMBO J. 1992 Jul;11(7):2541-50.

Abstract

We cloned two homeobox genes, Emx1 and Emx2, related to empty spiracles, a gene expressed in very anterior body regions during early Drosophila embryogenesis, and studied their expression in mouse embryos. Emx1 expression is detectable from day 9.5 of gestation whereas Emx2 appears to be already expressed in 8.5 day embryos. Both genes are expressed in the presumptive cerebral cortex and olfactory bulbs. Emx1 is expressed exclusively there, whereas Emx2 is also expressed in some neuroectodermal areas in embryonic head including olfactory placodes in earlier stages and olfactory epithelia later in development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Cerebral Cortex / embryology
  • Cerebral Cortex / metabolism*
  • Cloning, Molecular
  • DNA
  • Drosophila / genetics*
  • Female
  • Gene Expression
  • Genes, Homeobox*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Pregnancy
  • RNA Probes
  • Sequence Homology, Nucleic Acid

Substances

  • RNA Probes
  • DNA

Associated data

  • GENBANK/X66291
  • GENBANK/X66292
  • GENBANK/X66293
  • GENBANK/X66294
  • GENBANK/X67725
  • GENBANK/X67726
  • GENBANK/X68879
  • GENBANK/X68880
  • GENBANK/X68881
  • GENBANK/X68882