Nitric oxide and neurons

Curr Opin Neurobiol. 1992 Jun;2(3):323-7. doi: 10.1016/0959-4388(92)90123-3.


In the past 2 years powerful evidence has emerged to suggest that nitric oxide functions as a neurotransmitter in both the central and peripheral nervous systems. Recent evidence suggests that it may play a role in mediating forms of synaptic plasticity such as long-term potentiation in the CA1 region of the hippocampus, and long-term depression in the cerebellum. Abnormal secretion of nitric oxide may be responsible for the neurotoxicity mediated by NMDA receptors that results in the pathophysiology of strokes and neurodegenerative diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Neurons / physiology*
  • Neurotransmitter Agents / physiology*
  • Nitric Oxide* / metabolism


  • Neurotransmitter Agents
  • Nitric Oxide