Monoclonal antibody to MALA-2 (ICAM-1) reduces acute autoimmune nephritis in kdkd mice

Clin Immunol Immunopathol. 1992 Aug;64(2):129-34. doi: 10.1016/0090-1229(92)90190-y.


Hereditary tubulointerstitial nephritis is a prominent cause of renal failure in humans. A variety of animal models utilizing immunologically induced nephritis have been developed. The kdkd congenic variant of the CBA/Ca mouse has normal kidneys at birth but develops progressive, lethal autoimmune nephritis beginning at approximately Week 8. The destruction of renal tubular epithelium in mediated by a population of antigen-specific, H-2Kk-restricted, Lyt-2+, L3T4- T cells. The present experiments demonstrate that systemic treatment with anti-ICAM-1 monoclonal antibody reduces kidney disease in kdkd mice. Anti-ICAM-1 mab localizes to inflammatory sites in the kidney and effects a significant reduction in leukocyte infiltration. Concomitantly, urine protein levels of anti-ICAM-1-treated mice are significantly reduced. The use of anti-adhesion molecule monoclonal antibodies that alter leukocyte activity and/or trafficking may be useful therapies for certain autoimmune disorders.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Antigens, CD / immunology*
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy*
  • Cell Adhesion Molecules / immunology*
  • Cell Movement / immunology
  • Disease Models, Animal
  • Intercellular Adhesion Molecule-1
  • Kidney / chemistry
  • Kidney / immunology
  • Mice
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Nephritis, Interstitial / immunology
  • Nephritis, Interstitial / pathology
  • Nephritis, Interstitial / therapy*
  • Proteinuria / immunology
  • Proteinuria / therapy
  • Receptors, Antigen, T-Cell / immunology
  • Tumor Necrosis Factor Receptor Superfamily, Member 7


  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • Cell Adhesion Molecules
  • Receptors, Antigen, T-Cell
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Intercellular Adhesion Molecule-1