[Elevated serum levels of ICAM-1 in Wegener's granulomatosis]

Immun Infekt. 1992 Jul;20(3):84-5.
[Article in German]

Abstract

Circulating soluble ICAM-1 (sICAM-1) isoforms are known to be elevated in inflammatory and autoimmune disorders (SLE, RA). A correlation between levels of circulating sICAM-1 and disease activity was described (5). In sera from 31 patients suffering from histologically confirmed Wegener's granulomatosis (WG) elevated levels of ICAM-1 were now detected in this primary systemic vasculitis. In generalized active disease circulating ICAM-1 levels were significantly higher when compared to remission and healthy control individuals. Sera from WG patients collected during intercurrent infections while on immunosuppressive drugs showed no elevation of circulating ICAM-1.

Publication types

  • English Abstract

MeSH terms

  • Antigens, CD / blood
  • Cell Adhesion Molecules / blood*
  • Cell Adhesion Molecules / chemistry
  • Granulomatosis with Polyangiitis / blood*
  • Granulomatosis with Polyangiitis / drug therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Intercellular Adhesion Molecule-1
  • Solubility

Substances

  • Antigens, CD
  • Cell Adhesion Molecules
  • Immunosuppressive Agents
  • Intercellular Adhesion Molecule-1