DNA analysis in Turkish Duchenne/Becker muscular dystrophy families

Hum Genet. 1992 Aug;89(6):635-9. doi: 10.1007/BF00221954.


The molecular genetics of Duchenne/Becker muscular dystrophy was investigated in 81 affected Turkish families. Deletions were detected by multiplex polymerase chain reaction assays and cDNA Southern analyses. The distribution of the deletions along the gene and their correlation to clinical phenotype were different from the studies reported on other populations. Moreover, DNA polymorphisms in mothers were determined using 8 DNA probes and three CA repeat sequences, and a high degree of informativeness was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Deletion*
  • DNA Mutational Analysis
  • Humans
  • Male
  • Muscular Dystrophies / genetics*
  • Phenotype
  • Polymorphism, Restriction Fragment Length
  • Turkey