Oral cancer progression and c-erbB-2/neu proto-oncogene expression

Cancer Lett. 1992 Aug 31;65(3):215-20. doi: 10.1016/0304-3835(92)90234-m.


Monoclonal antibody PAb3 to c-erbB-2/neu protein was utilized in the immunoperoxidase staining of 86 human specimens from oral mucosa. These tissue specimens represented a spectrum from 7 normal to 9 simple hyperplasia, 15 mild dysplasia, 14 moderate dysplasia, 20 severe dysplasia and 21 squamous cell carcinoma. Our study indicated that as the cells acquire a more malignant phenotype, there was a progressive increase in neu expression. It also suggested that neu may be involved in the development of oral cancers and that its evaluation in the early stages may assist in the diagnosis and management of oral cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / enzymology
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology
  • Cell Transformation, Neoplastic / genetics
  • Chi-Square Distribution
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunoenzyme Techniques
  • Mouth Neoplasms / enzymology
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology
  • Precancerous Conditions / enzymology
  • Precancerous Conditions / genetics*
  • Protein-Tyrosine Kinases / genetics
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • Receptor, ErbB-2


  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Receptor, ErbB-2