Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors

Eur J Pharmacol. 1992 Mar 12;225(3):217-23. doi: 10.1016/0922-4106(92)90023-o.

Abstract

Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.

MeSH terms

  • Animals
  • Brain / physiology
  • Brain Chemistry / physiology
  • Brain Mapping*
  • Dizocilpine Maleate / pharmacology
  • Ethanol / blood
  • Ethanol / pharmacology*
  • Glutamates / physiology*
  • Glutamic Acid
  • Male
  • Proto-Oncogene Proteins c-fos / biosynthesis
  • RNA, Messenger / analysis
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Second Messenger Systems / drug effects
  • Second Messenger Systems / physiology
  • Stereoisomerism
  • Substance Withdrawal Syndrome / physiopathology*

Substances

  • Glutamates
  • Proto-Oncogene Proteins c-fos
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate
  • Ethanol
  • Glutamic Acid
  • Dizocilpine Maleate