Protein oxidation and aging

Science. 1992 Aug 28;257(5074):1220-4. doi: 10.1126/science.1355616.


A number of systems that generate oxygen free radicals catalyze the oxidative modification of proteins. Such modifications mark enzymes for degradation by cytosolic neutral alkaline proteases. Protein oxidation contributes to the pool of damaged enzymes, which increases in size during aging and in various pathological states. The age-related increase in amounts of oxidized protein may reflect the age-dependent accumulation of unrepaired DNA damage that, in a random manner, affects the concentrations or activities of numerous factors that govern the rates of protein oxidation and the degradation of oxidized protein.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Enzymes / physiology
  • Gerbillinae
  • Glutamate-Ammonia Ligase
  • Humans
  • Hydrogen Peroxide
  • Oxidation-Reduction
  • Proteins / metabolism*


  • Enzymes
  • Proteins
  • Hydrogen Peroxide
  • Glutamate-Ammonia Ligase