Does rilmenidine act in vivo on central alpha 2-adrenoceptors modulating noradrenaline release?

Eur J Pharmacol. 1992 Mar 24;213(2):305-7. doi: 10.1016/0014-2999(92)90696-2.

Abstract

Noradrenaline release evoked by electrical stimulation was recorded in the rat hypothalamus by in vivo electrochemistry. Rilmenidine (0.3-10 mg kg-1 i.v.) did not diminish this evoked release while clonidine induced a dose-dependent decrease. These results further suggest that the antihypertensive action of rilmenidine is not mediated by central alpha 2-adrenoceptors and might explain why, unlike clonidine, rilmenidine does not have sedative effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Agonists / pharmacology
  • Animals
  • Antihypertensive Agents / pharmacology*
  • Clonidine / pharmacology
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Hypothalamus / drug effects*
  • Hypothalamus / metabolism
  • Norepinephrine / metabolism*
  • Oxazoles / pharmacology*
  • Rats
  • Receptors, Adrenergic, alpha / drug effects
  • Receptors, Adrenergic, alpha / physiology*
  • Rilmenidine

Substances

  • Adrenergic alpha-Agonists
  • Antihypertensive Agents
  • Oxazoles
  • Receptors, Adrenergic, alpha
  • Clonidine
  • Rilmenidine
  • Norepinephrine