Inhibition of hormone-sensitive lipase by intermediary lipid metabolites

C A Jepson; S J Yeaman

doi:10.1016/0014-5793(92)81328-j

Inhibition of hormone-sensitive lipase by intermediary lipid metabolites

FEBS Lett. 1992 Sep 28;310(2):197-200. doi: 10.1016/0014-5793(92)81328-j.

Authors

C A Jepson¹, S J Yeaman

Affiliation

¹ Department of Biochemistry and Genetics, University of Newcastle upon Tyne, UK.

PMID: 1356829
DOI: 10.1016/0014-5793(92)81328-j

Abstract

Hormone-sensitive lipase (HSL) is inhibited in a non-competitive manner by oleoyl CoA, oleic acid and 2-monopalmitoylglycerol, 50% inhibition being observed at concentrations of approx. 0.1 microM, 0.5 microM and 500 microM, respectively. HSL is a key enzyme in lipid metabolism, mobilising triacylglycerol and cholesterol ester stores in several tissues. Feedback inhibition of HSL by oleoyl CoA and oleic acid may therefore prevent accumulation of free fatty acids and cholesterol in the cell, whereas 2-monoacylglycerol may act as a feedback inhibitor if the capacity of monoacylglycerol lipase is exceeded.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetyl-CoA Carboxylase / antagonists & inhibitors
Adipose Tissue / enzymology
Animals
Cattle
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lipid Metabolism*
Sterol Esterase / antagonists & inhibitors*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Sterol Esterase
Acetyl-CoA Carboxylase