Fatal myocardial infarction and use of psychotropic drugs in young women

Lancet. 1992 Oct 31;340(8827):1067-8. doi: 10.1016/0140-6736(92)93081-w.

Abstract

We have observed an unexpected 17-fold increase in risk of fatal [corrected] myocardial infarction (relative risk 16.9, 95% confidence interval 3.9-72.8) associated with current use of psychotropic drugs. This incidental finding, in a case-control study of cardiovascular mortality in women aged 16-39 not designed to test any hypothesis about psychotropic drugs, should be treated cautiously. There is, however, evidence of a relation between psychiatric morbidity and cardiovascular disease and the association recorded here requires further investigation.

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Myocardial Infarction / chemically induced*
  • Myocardial Infarction / mortality
  • Psychotropic Drugs / adverse effects*
  • Risk Factors
  • Subarachnoid Hemorrhage / chemically induced
  • Thrombophlebitis / chemically induced
  • United Kingdom / epidemiology

Substances

  • Psychotropic Drugs