Epidermal Growth Factor Receptor and Bladder Cancer: A Review

Urol Int. 1992;48(4):365-71. doi: 10.1159/000282357.

Abstract

Recently, expectations have been raised that molecular biological studies of human tumours may be of value in helping to predict future clinical behaviour, in terms of therapeutic response and long-term survival. The epidermal growth factor receptor (EGFr) is a cell surface receptor for EGF and transforming growth factor-alpha which is overexpressed by a number of human tumours. This article principally reviews previous investigations of the role of the epidermal growth factor receptor in bladder cancer and examines methods of detection, the correlation between EGFr status and known prognostic indicators and the value of assessing EGFr status in predicting clinical outcome in patients with bladder cancer. Recent studies of the c-erbB-2 proto-oncogene in bladder cancer and of cell cycling using Ki-67 are included.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Epidermal Growth Factor / genetics
  • Epidermal Growth Factor / metabolism
  • ErbB Receptors / genetics
  • ErbB Receptors / metabolism*
  • Humans
  • Neoplasm Metastasis
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism
  • Neoplasm Recurrence, Local / metabolism
  • Prognosis
  • Proto-Oncogene Proteins / metabolism
  • Receptor, ErbB-2
  • Transforming Growth Factor alpha / metabolism*
  • Urinary Bladder Neoplasms / genetics
  • Urinary Bladder Neoplasms / metabolism*
  • Urinary Bladder Neoplasms / mortality
  • Urinary Bladder Neoplasms / pathology

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Transforming Growth Factor alpha
  • Epidermal Growth Factor
  • ErbB Receptors
  • Receptor, ErbB-2