Serum levels of vitamin D metabolites in isotretinoin-treated acne patients

Acta Derm Venereol. 1992;72(3):217-9.


Serum levels of vitamin D metabolites were determined in 11 patients treated for cystic acne with a four-month course of isotretinoin (Roaccutane). The levels were measured before treatment and after two months of medication. We found a significant fall in the level of 1,25-dihydroxyvitamin D (p less than 0.01) and a significant increase in the molar ratio of 24, 25-dihydroxyvitamin D to 25-hydroxyvitamin D (p less than 0.05). No significant changes were found for the vitamin D metabolites 25-hydroxyvitamin D or 24,25-dihydroxy-vitamin D, for serum calcium, phosphorus, alkaline phosphatase or parathyroid hormone. Our data indicate early changes in the metabolism of vitamin D in patients on retinoid treatment.

MeSH terms

  • Acne Vulgaris / blood*
  • Acne Vulgaris / drug therapy*
  • Adolescent
  • Adult
  • Calcifediol / blood*
  • Calcium / blood
  • Ergocalciferols / blood*
  • Female
  • Humans
  • Isotretinoin / therapeutic use*
  • Male
  • Middle Aged
  • Time Factors


  • Ergocalciferols
  • 1,25-dihydroxyergocalciferol
  • 24,25-dihydroxyvitamin D2
  • Isotretinoin
  • Calcifediol
  • Calcium