Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients

Acta Derm Venereol. 1992 Aug;72(4):250-2.


To explore the mechanism by which zinc acts on cutaneous inflammatory lesions, we studied granulocyte zinc levels and in vitro polymorphonuclear leukocyte chemotaxis in 20 acne patients before and after 2 months of zinc therapy (200 mg/day zinc gluconate). The zinc level was assayed by flame absorption spectrophotometry and chemotaxis was performed by agarose assay. After 2 months of treatment, a significant decrease in granulocyte zinc level associated with inhibition of chemotaxis (r = 0.69) was observed in 16 patients. This suggests that zinc anti-inflammatory action is related to inhibition of polymorphonuclear leukocyte chemotaxis induced by a decreased granulocyte zinc level.

MeSH terms

  • Acne Vulgaris / drug therapy
  • Acne Vulgaris / pathology*
  • Adolescent
  • Adult
  • Chemotaxis, Leukocyte / drug effects*
  • Female
  • Gluconates / pharmacology*
  • Gluconates / therapeutic use
  • Granulocytes / chemistry
  • Granulocytes / drug effects*
  • Humans
  • Male
  • Neutrophils / drug effects
  • Spectrophotometry
  • Zinc / analysis*


  • Gluconates
  • Zinc
  • gluconic acid