Interaction between glutamatergic and dopaminergic tone in the nucleus accumbens of mice: evidence for a dual glutamatergic function with respect to psychomotor control

J Neural Transm Gen Sect. 1992;88(3):235-40. doi: 10.1007/BF01244735.


The rotation induced by a unilateral injection of the competitive NMDA receptor antagonist AP-5 was studied in mice with different tone in the central dopaminergic systems. AP-5 induced contralateral rotation in monoamine-depleted mice and in monoamine-depleted mice treated with a dopamine D-1 receptor agonist. In contrast, AP-5 induced predominantly ipsilateral rotation in monoamine-depleted mice treated with a mixed D-1/D-2 or a D-2 selective dopamine agonist and in mice with intact monoaminergic systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • 2-Amino-5-phosphonovalerate / pharmacology
  • Animals
  • Behavior, Animal / drug effects
  • Dopamine / physiology*
  • Dopamine Agents / pharmacology
  • Ergolines / pharmacology
  • Glutamates / physiology*
  • Male
  • Mice
  • Nucleus Accumbens / physiology*
  • Quinpirole
  • Stereotyped Behavior / drug effects*


  • Dopamine Agents
  • Ergolines
  • Glutamates
  • Quinpirole
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • 2-Amino-5-phosphonovalerate
  • Dopamine