Abstract
The rotation induced by a unilateral injection of the competitive NMDA receptor antagonist AP-5 was studied in mice with different tone in the central dopaminergic systems. AP-5 induced contralateral rotation in monoamine-depleted mice and in monoamine-depleted mice treated with a dopamine D-1 receptor agonist. In contrast, AP-5 induced predominantly ipsilateral rotation in monoamine-depleted mice treated with a mixed D-1/D-2 or a D-2 selective dopamine agonist and in mice with intact monoaminergic systems.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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2-Amino-5-phosphonovalerate / pharmacology
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Animals
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Behavior, Animal / drug effects
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Dopamine / physiology*
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Dopamine Agents / pharmacology
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Ergolines / pharmacology
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Glutamates / physiology*
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Male
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Mice
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Nucleus Accumbens / physiology*
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Quinpirole
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Stereotyped Behavior / drug effects*
Substances
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Dopamine Agents
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Ergolines
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Glutamates
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Quinpirole
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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2-Amino-5-phosphonovalerate
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Dopamine