Clostridium difficile infection: responses, relapses and re-infections

J Hosp Infect. 1992 Oct;22(2):85-92. doi: 10.1016/0195-6701(92)90092-z.


Clostridium difficile infection is a common and potentially lethal complication of antibiotic usage. Since the aetiology of antibiotic-associated colitis was discovered 14 years ago, two antibiotics in particular, metronidazole and vancomycin, have been used to treat C. difficile infection. Studies comparing the efficacy of these antibiotics are reviewed. It is now apparent that many of the so-called 'relapses' of C. difficile infection following antibiotic treatment are, in fact, re-infections. Such findings have major infection control implications.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Clinical Trials as Topic
  • Cross Infection / drug therapy*
  • Cross Infection / epidemiology
  • Cross Infection / prevention & control
  • Disease Outbreaks
  • Enterocolitis, Pseudomembranous / drug therapy*
  • Enterocolitis, Pseudomembranous / epidemiology
  • Enterocolitis, Pseudomembranous / prevention & control
  • Humans
  • Infection Control / methods
  • Metronidazole / therapeutic use*
  • Recurrence
  • Vancomycin / therapeutic use*


  • Metronidazole
  • Vancomycin