Abstract
Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanolic acid checked the inflammation-induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan-induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil-induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg-1 in mice and rats.
MeSH terms
-
Adrenalectomy
-
Animals
-
Anti-Inflammatory Agents
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Anti-Inflammatory Agents, Non-Steroidal / toxicity
-
Arthritis, Experimental / drug therapy
-
Behavior, Animal / drug effects
-
Carrageenan
-
Diarrhea / chemically induced
-
Diarrhea / prevention & control
-
Edema / chemically induced
-
Edema / prevention & control
-
Female
-
Formaldehyde
-
Gossypium
-
Labor, Obstetric / drug effects
-
Male
-
Mice
-
Oleanolic Acid / pharmacology*
-
Oleanolic Acid / toxicity
-
Pleurisy / chemically induced
-
Pleurisy / prevention & control
-
Pregnancy
-
Rats
-
Seeds / chemistry
-
Stomach Ulcer / chemically induced
-
Transaminases / blood
Substances
-
Anti-Inflammatory Agents
-
Anti-Inflammatory Agents, Non-Steroidal
-
Formaldehyde
-
Oleanolic Acid
-
Carrageenan
-
Transaminases