A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

Brain Res Mol Brain Res. 1992 Sep;15(1-2):161-6. doi: 10.1016/0169-328x(92)90165-8.

Abstract

We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3' untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blotting, Southern
  • Carrier Proteins / biosynthesis*
  • Cloning, Molecular
  • Continental Population Groups / genetics*
  • DNA / genetics*
  • Deoxyribonucleases, Type II Site-Specific / genetics*
  • Dopamine Plasma Membrane Transport Proteins
  • Glycosylation
  • Humans
  • In Situ Hybridization
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Molecular Sequence Data
  • Nerve Tissue Proteins*
  • Polymorphism, Restriction Fragment Length*
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Alignment

Substances

  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • DNA
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases

Associated data

  • GENBANK/M95167