Cadmium inhibits stimulus-response coupling in skate (Raja erinacea) electric organ

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Jul;102(3):439-46. doi: 10.1016/0742-8413(92)90139-x.

Abstract

1. The effects of cadmium on stimulus-response coupling in the skate (Raja erinacea) electric organ were examined. 2. Cadmium decreased the evoked electrical discharge and the evoked release of 3H-ACh in a concentration-related fashion. 3. Cadmium (100 microM) also blocked voltage-dependent 45Ca uptake. 4. Both d-tubocurarine and nifedipine blocked Ca uptake and evoked potential, but not 3H-ACh release, thus most of the 45Ca uptake measured was post-synaptic through L Ca channels. 5. Nickel, cadmium, and verapamil inhibited 3H-ACh release and evoked potential, indicating a block of pre-synaptic T Ca channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcholine / metabolism
  • Animals
  • Cadmium / toxicity*
  • Calcium / metabolism
  • Choline / metabolism
  • Electric Organ / drug effects*
  • Electric Organ / physiology
  • Electric Stimulation
  • Evoked Potentials / drug effects
  • In Vitro Techniques
  • Skates, Fish / physiology*

Substances

  • Cadmium
  • Choline
  • Acetylcholine
  • Calcium